Michael Jackson was anything but a typical middle-aged American man.
And he certainly didn't fit the popular image of a guy at risk for sudden cardiac arrest. An overweight, hard drinking, 60-something male, who smokes and lives on fast food, yes. But not thin-as-a-rail, dancer extraordinaire Michael Jackson, who died Thursday at age 50 as he was about to embark on a series of London performances. (When this photo was taken in March, he was announcing those shows, which promptly sold out).
What might have happened to stop his heart?
Reports that he might have received a high dose of Demerol, a synthetic narcotic similar to morphine, were rampant Friday. The Los Angeles County Coroner's Office was expected to hold a press conference later tonight, although it could be weeks before complete toxicology reports are complete.
But even beyond the Demerol, some Tampa Bay area medical experts say it's not difficult to imagine the possibilities.
In cases of sudden cardiac arrest, cardiologists first suspect undiagnosed coronary artery disease, small plaque deposits in the arteries of the heart, said Tampa cardiologist John Dormois. This is the bad cholesterol we hear so much about. These deposits become a problem if their thin covering ruptures, launching a potentially deadly chain of events.
First, the body responds to the rupture by signaling the blood to immediately form clots. These clots quickly fill the artery and within minutes can completely block blood flow to the heart and other vital organs. This interruption in blood flow throws the heart into a potentially lethal, abnormal rhythm, where it quivers rather than beats steadily. When that happens, the patient needs immediate CPR or an AED, a mechanical device that shocks the heart back to a normal rhythm. “If not restored within 5 minutes, the patient will most certainly suffer brain damage. After 10 minutes there is no chance for recovery. You probably die,” Dormois said.
Next on the list of possible causes of cardiac arrest is a drug interaction. “This is a big concern,” says University Community Hospital interventional cardiologist Carlos Leche. And it doesn't have to be anything exotic. Over-the-counter medications commonly taken for colds and flu can interact with common prescription drugs, triggering an abnormal heartbeat. “The group that we’re most concerned with are antibiotics known as quinolones,” says Leche. They are prescribed to treat everything from nail fungus to pneumonia.
Quinolones are particularly dangerous when combined with medications for anxiety, pain, insomnia and some older antidepressants. Together, they can set off a deadly electrical storm in the heart. That’s one of the reasons doctors always ask patients about all their medications.
“We always tell our patients to ask us first before taking anything prescribed by another doctor, to make sure it’s safe,” Dormois said.
Doctors must rely on their patients for this critical information or on an alert pharmacist who catches a potential problem before filling a prescription. But that isn’t fool-proof.
“When patients have prescriptions filled at several different pharmacies, there’s no way to check for drug interactions,'' said Tampa General Hospital Pharmacist Drew Silverman. Some chronic pain sufferers, he said, deliberately fill prescriptions all around town, so it doesn’t appear to any one pharmacist as though they are taking too much of a particular drug.
Finally, sudden cardiac arrest can result from an overdose of any sedating medication, whether taken alone or in combination with other drugs. One such drug is Demerol. In high doses, sedatives can suppress the part of the brain that controls respiration, causing you to stop breathing. “Your blood oxygen level goes so low, it can trigger sudden cardiac arrest,” Leche said.
Bottom line: Michael Jackson was no ordinary man. But the experts agree that his sad end is an opportunity for people who think they are safe from a cardiac disaster to reconsider, and take health precautions that could save their lives.
Irene Maher, Times staff writer
Photo: AP
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